Budget
Pi
Wood-fired Pizza. Somewhat limited menu, with very unusual ingredients.
Midrange
Roscoe's Barbecue
BBQ, award-winning ribs, and home-made root beer. Given how far north Rochester is, the BBQ in town is surprising good. Roscoe's is one of the two local places, along with John Hardy's. The chain Famous Dave's also has a branch in town. Ask a Rochester local, odds are they'll have a strong opinion on which of the three BBQ places is the best.
Top end
City Cafe
Modern American. Voted Best Restaurant in Rochester Magazine poll in 2006, 2007, 2008.
Michael's
Traditional American, steaks. Go for the pictures of famous people on the wall who have eaten there. Voted Best Steak Dinner in Rochester Magazine poll in 2009.
Chester's Kitchen and Bar
Traditional American with a twist, most popular restaurant in town. Voted Best Restaurant in Rochester Magazine poll in 2010, 2011 and 2012.
Pescara
Opened May 2009, probably the best seafood in town. Smallish but fancy dining area.
Prescott
Bistro-style French, casual but with great food. Smaller but excellent wine list. Voted Best Restaurant in Rochester Magazine poll in 2009.
Söntés
Tapas with extensive wine list, gourmet cheeses.
Pazzo
Traditional and modern Italian. Below 300 First. Voted Best New Restaurant in Rochester Magazine poll in 2011.
ZZest Market and Wine Café
New American. Most creative menu in town, changes daily. Part of a gourmet grocery store.
Grocery stores
Trader Joe's
Specialty grocery store with items that you likely won't find elsewhere.